AbstractIn this review, we describe research findings on the effects of alcohol exposure on two major catabolic systems in liver cells: the ubiquitin–proteasome system (UPS) and autophagy. These hydrolytic systems are not unique to liver cells; they exist in all eukaryotic tissues and cells. However, because the liver is the principal site of ethanol metabolism, it sustains the greatest damage from heavy drinking. Thus, the focus of this review is to specifically describe how ethanol oxidation modulates the activities of the UPS and autophagy and the mechanisms by which these changes contribute to the pathogenesis of alcohol-induced liver injury. Here, we describe the history and the importance of cellular hydrolytic systems, followed by a ...
The following review article presents clinical and experimental features of alcohol-induced liver di...
1. The biochemical mechanisms of the alcohol-induced liver injury are reviewed. 2. Acute alcohol int...
Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, hear...
In this review, we describe research findings on the effects of alcohol exposure on two major catabo...
In this review, we describe research findings on the effects of alcohol exposure on two major catabo...
The proteasome and autophagy are two major intracellular protein degradation pathways and the regula...
Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived proteins and...
Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cell...
Most eukaryotic cells, including hepatocytes, secrete exosomes into the extracellular space, which a...
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of alcohol-in...
Alcohol consumption alters the metabolism of the most common type of cell found in the liver, the he...
AbstractWe have explored the mechanisms underlying ethanol-induced mitochondrial dynamics disruption...
Abstract Chronic alcohol consumption is a well-known risk factor for liver disease, which represents...
The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively ...
Acute and chronic alcohol consumption increases the production of reactive oxygen species (ROS), and...
The following review article presents clinical and experimental features of alcohol-induced liver di...
1. The biochemical mechanisms of the alcohol-induced liver injury are reviewed. 2. Acute alcohol int...
Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, hear...
In this review, we describe research findings on the effects of alcohol exposure on two major catabo...
In this review, we describe research findings on the effects of alcohol exposure on two major catabo...
The proteasome and autophagy are two major intracellular protein degradation pathways and the regula...
Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived proteins and...
Macroautophagy (autophagy) is an evolutionarily conserved mechanism. It is important for normal cell...
Most eukaryotic cells, including hepatocytes, secrete exosomes into the extracellular space, which a...
Chronic alcohol consumption is a well-known risk factor for liver disease. Progression of alcohol-in...
Alcohol consumption alters the metabolism of the most common type of cell found in the liver, the he...
AbstractWe have explored the mechanisms underlying ethanol-induced mitochondrial dynamics disruption...
Abstract Chronic alcohol consumption is a well-known risk factor for liver disease, which represents...
The molecular mechanisms that lead to the progression of alcoholic liver disease have been actively ...
Acute and chronic alcohol consumption increases the production of reactive oxygen species (ROS), and...
The following review article presents clinical and experimental features of alcohol-induced liver di...
1. The biochemical mechanisms of the alcohol-induced liver injury are reviewed. 2. Acute alcohol int...
Alcohol consumption leads to injury in multiple organs and systems, including the liver, brain, hear...