Extreme Heterogeneity in the Molecular Events Leading to the Establishment of Chiasmata during Meiosis I in Human Oocytes
- Lenzi, Michelle L.
- Smith, Jenetta
- Snowden, Timothy
- Kim, Mimi
- Fishel, Richard
- Poulos, Bradford K.
- Cohen, Paula E.
DOIAbstract
In humans, ∼50% of conceptuses are chromosomally aneuploid as a consequence of errors in meiosis, and most of these aneuploid conceptuses result in spontaneous miscarriage. Of these aneuploidy events, 70% originate during maternal meiosis, with the majority proposed to arise as a direct result of defective crossing over during meiotic recombination in prophase I. By contrast, <1%–2% of mouse germ cells exhibit prophase I–related nondisjunction events. This disparity among mammalian species is surprising, given the conservation of genes and events that regulate meiotic progression. To understand the mechanisms that might be responsible for the high error rates seen in human females, we sought to further elucidate the regulation of meiotic pr...
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