AbstractLens arises from ectoderm situated next to the optic vesicles. By thickening and invaginating, the ectoderm forms the lens vesicle. Growth factors are key regulators of cell fate and behavior. Current evidence indicates that FGFs and BMPs are required to induce lens differentiation from ectoderm. In the lens vesicle, posterior cells elongate to form the primary fibers whereas anterior cells differentiate into epithelial cells. The divergent fates of these embryonic cells give the lens its distinctive polarity. There is now compelling evidence that, at least in mammals, FGF is required to initiate fiber differentiation and that progression of this complex process depends on the synchronized and integrated action of a number of distin...
FGF-3, originally named int-2, was discovered as an oncogene frequently activated in mammary carcino...
The Wnt/b-catenin signaling pathway controls many processes during development, including cell proli...
Duncan, Melinda K.Lens epithelial cells differentiate into lens fibers (LF) in response to a gradien...
AbstractLens arises from ectoderm situated next to the optic vesicles. By thickening and invaginatin...
The lens is a good developmental biology model owing to its simplicity and distinct polarity. The a...
AbstractHow an organ develops its characteristic shape is a major issue. This is particularly critic...
AbstractThe differentiation of epithelial cells and fiber cells from the anterior and posterior comp...
AbstractThe vertebrate lens provides anin vivomodel to study the molecular mechanisms by which growt...
AbstractIt is widely accepted that vitreous humor-derived FGFs are required for the differentiation ...
LIM-homeodomain transcription factor Lhx2 is an essential regulator of mammalian eye development. To...
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate ...
AbstractThe vertebrate lens provides an excellent model to study the mechanisms that regulate termin...
The nervous system is composed of two separate compartments, the central and the peripheral nervous ...
AbstractTo determine if fibroblast growth factor signaling mechanisms are required for terminal diff...
AbstractFGF-3, originally named int-2, was discovered as an oncogene frequently activated in mammary...
FGF-3, originally named int-2, was discovered as an oncogene frequently activated in mammary carcino...
The Wnt/b-catenin signaling pathway controls many processes during development, including cell proli...
Duncan, Melinda K.Lens epithelial cells differentiate into lens fibers (LF) in response to a gradien...
AbstractLens arises from ectoderm situated next to the optic vesicles. By thickening and invaginatin...
The lens is a good developmental biology model owing to its simplicity and distinct polarity. The a...
AbstractHow an organ develops its characteristic shape is a major issue. This is particularly critic...
AbstractThe differentiation of epithelial cells and fiber cells from the anterior and posterior comp...
AbstractThe vertebrate lens provides anin vivomodel to study the molecular mechanisms by which growt...
AbstractIt is widely accepted that vitreous humor-derived FGFs are required for the differentiation ...
LIM-homeodomain transcription factor Lhx2 is an essential regulator of mammalian eye development. To...
During terminal differentiation, lens fiber cells permanently withdraw from the cell cycle, migrate ...
AbstractThe vertebrate lens provides an excellent model to study the mechanisms that regulate termin...
The nervous system is composed of two separate compartments, the central and the peripheral nervous ...
AbstractTo determine if fibroblast growth factor signaling mechanisms are required for terminal diff...
AbstractFGF-3, originally named int-2, was discovered as an oncogene frequently activated in mammary...
FGF-3, originally named int-2, was discovered as an oncogene frequently activated in mammary carcino...
The Wnt/b-catenin signaling pathway controls many processes during development, including cell proli...
Duncan, Melinda K.Lens epithelial cells differentiate into lens fibers (LF) in response to a gradien...