Detection of Lipid Core Coronary Plaques in Autopsy Specimens With a Novel Catheter-Based Near-Infrared Spectroscopy System
- Gardner, Craig M.
- Tan, Huwei
- Hull, Edward L.
- Lisauskas, Jennifer B.
- Sum, Stephen T.
- Meese, Thomas M.
- Jiang, Chunsheng
- Madden, Sean P.
- Caplan, Jay D.
- Burke, Allen P.
- Virmani, Renu
- Goldstein, James
- Muller, James E.
DOIAbstract
ObjectivesThis study sought to assess agreement between an intravascular near-infrared spectroscopy (NIRS) system and histology in coronary autopsy specimens.BackgroundLipid core plaques cannot be detected by conventional tests, yet are suspected to be the cause of most acute coronary syndromes. Near-infrared spectroscopy is widely used to determine the chemical content of substances. A NIRS system has been developed and used successfully in 99 patients.MethodsScanning NIRS was performed through blood in 212 coronary segments from 84 autopsy hearts. One histologic section was analyzed for every 2 mm of artery. Lipid core plaque of interest (LCP) was defined as a lipid core >60° in circumferential extent, >200-μm thick, with a mean fibrous c...
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