A safe protocol for rapid desensitization in patients with cystic fibrosis and antibiotic hypersensitivity

Legere, Henry J.
Palis, Ross I.
Bouza, Tito Rodriguez
Uluer, Ahmet Z.
Castells, Mariana C.

Open link

Publication date

December 2009

DOI

10.1016/j.jcf.2009.08.002

Publisher

Elsevier B.V.

Abstract

AbstractBackgroundCF patients often demonstrate hypersensitivity to one or multiple antibiotics due to frequent and repeated exposures. Attempts at antibiotic desensitization in this population are historically complicated by higher reaction rates, failure to complete the procedure and consequent withholding of first-line therapy. This study evaluates the outcomes of a rapid desensitization protocol developed at our institution.MethodsWe retrospectively reviewed the medical records of 15 patients undergoing 52 rapid antibiotic desensitizations at Brigham and Women's Hospital and Children's Hospital Boston utilizing our protocol.ResultsMean FEV1 % predicted was 44.1 (SD 16.5), with two patients at <30% and one patient desensitized during bil...