MicroRNAs (miRNAs) are important post-transcriptional regulators. Altered expression of miRNAs has recently demonstrated association with human ulcerative colitis (UC). In this study, we attempted to elucidate the roles of miR-126 in the pathogenesis of UC.Expression of miR-126, miR-21, miR-375 and the potential targets NF-κB inhibitor alpha (IκBα, IKBA or NFKBIA), Polo-like kinase 2 (PLK2) and v-Crk sarcoma virus CT10 oncogene homolog (CRK) were assessed in 52 colonic biopsies from patients with active UC, inactive UC, irritable bowel syndrome (IBS) and from healthy subjects by quantitative RT-PCR and immunofluorescence analyses. Regulation of gene expression by miR-126 was assessed using luciferase reporter construct assays and specific m...
BACKGROUND AND AIM:MicroRNAs are small non-coding RNAs that play an important role in regulating the...
Background & aimsPersistent activation of the inflammatory response contributes to the developme...
BACKGROUND: Evidence suggests the central role of tumor necrosis factor (TNF)-alpha in the pathomech...
<div><h3>Background</h3><p>MicroRNAs (miRNAs) are important post-transcriptional regulators. Altered...
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, which usually manifest...
BACKGROUND: Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Dise...
Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Diseases (IBD) a...
Background & aimsAltered levels and functions of microRNAs (miRs) have been associated with infl...
BACKGROUND: Ulcerative colitis (UC) is associated with differential colonic expression of genes invo...
Ulcerative Colitis (UC) is a type of inflammatory bowel disease, considered as an important disease ...
Background & Aims Persistent activation of the inflammatory response contributes to the developm...
Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functi...
BackgroundTwenty to 25% of the patients with inflammatory bowel disease (IBD) present the disease be...
Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functi...
International audienceBACKGROUND: Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic I...
BACKGROUND AND AIM:MicroRNAs are small non-coding RNAs that play an important role in regulating the...
Background & aimsPersistent activation of the inflammatory response contributes to the developme...
BACKGROUND: Evidence suggests the central role of tumor necrosis factor (TNF)-alpha in the pathomech...
<div><h3>Background</h3><p>MicroRNAs (miRNAs) are important post-transcriptional regulators. Altered...
Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease, which usually manifest...
BACKGROUND: Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Dise...
Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic Inflammatory Bowel Diseases (IBD) a...
Background & aimsAltered levels and functions of microRNAs (miRs) have been associated with infl...
BACKGROUND: Ulcerative colitis (UC) is associated with differential colonic expression of genes invo...
Ulcerative Colitis (UC) is a type of inflammatory bowel disease, considered as an important disease ...
Background & Aims Persistent activation of the inflammatory response contributes to the developm...
Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functi...
BackgroundTwenty to 25% of the patients with inflammatory bowel disease (IBD) present the disease be...
Interleukin-13 (IL-13) is an important Type 2 T helper (Th2) cytokine, controlling biological functi...
International audienceBACKGROUND: Ulcerative Colitis (UC) and Crohn's Disease (CD) are two chronic I...
BACKGROUND AND AIM:MicroRNAs are small non-coding RNAs that play an important role in regulating the...
Background & aimsPersistent activation of the inflammatory response contributes to the developme...
BACKGROUND: Evidence suggests the central role of tumor necrosis factor (TNF)-alpha in the pathomech...