Skin Autofluorescence, a Non-Invasive Marker for AGE Accumulation, Is Associated with the Degree of Atherosclerosis
- den Dekker Martijn A. M.
- Zwiers Marjan
- van den Heuvel Edwin R.
- de Vos Lisanne C.
- Smit Andries J.
- Zeebregts Clark J.
- Oudkerk Matthijs
- Vliegenthart Rozemarijn
- Lefrandt Joop D.
- Mulder Douwe J.
DOIAbstract
Advanced glycation endproducts (AGEs) may be involved in the development of atherosclerosis, beyond diabetes and renal disease. Skin autofluorescence (AF) is a non-invasive marker for AGEs. We examined whether skin AF is increased in (subclinical) atherosclerosis and associated with the degree of atherosclerosis independent of diabetes and renal function. = 67; age 53 year [interquartile range 48–56]; 49% male) and without (controls; 96; 43 [38–51]; 55%). Secondary prevention were patients with peripheral arterial disease (60; 64 [58–70]; 73%). = 0.005 and <0.001). In a multivariate analysis, the association of skin AF with the atherosclerosis categories was independent of age, sex, diabetes, presence of the metabolic syndrome, Framingham R...
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