LDL Receptor Knock-Out Mice Are a Physiological Model Particularly Vulnerable to Study the Onset of Inflammation in Non-Alcoholic Fatty Liver Disease
- Bieghs Veerle
- Van Gorp Patrick J.
- Wouters Kristiaan
- Hendrikx Tim
- Gijbels Marion J.
- van Bilsen Marc
- Bakker Jaap
- Binder Christoph J.
- Lütjohann Dieter
- Staels Bart
- Hofker Marten H.
- Shiri-Sverdlov Ronit
DOIAbstract
mice. However, it is not known whether the early inflammatory response observed in these mice will sustain over time and lead to liver damage. We hypothesized that the inflammatory response in both models is sufficient to induce liver damage over time. mice were fed a chow or HFC diet for 3 months. C57Bl6/J mice were used as control. mice. mice are a promising physiological model particularly vulnerable for investigating the onset of hepatic inflammation in non-alcoholic steatohepatitis
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