Regulatory T Cells Suppress Anti-Tumor Immune Responses in Patients with Colorectal Cancer
- Clarke Sarah L.
- Betts Gareth J.
- Plant Andrea
- Wright Kate L.
- El-Shanawany Tariq M.
- Harrop Richard
- Torkington Jared
- Rees Brian I.
- Williams Geraint T.
- Gallimore Awen M.
- Godkin Andrew J.
DOIAbstract
T cell responses in patients with colorectal cancer (CRC). We set out to measure T cell responses to a tumor-associated antigen and examine whether Treg impinge on those anti-tumor immune responses in CRC patients. T cell responses, as observed by IFNγ release, to the tumor associated antigen 5T4, whereas no effect was observed in a healthy age-matched control group.Collectively, these data demonstrate that Treg capable of inhibiting tumor associated antigen-specific immune responses are enriched in patients with CRC. These results support a rationale for manipulating Treg to enhance cancer immunotherapy
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