Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface scale formation, and marked cutaneous inflammation. To better understand the pathogenesis of this disease and identify potential mediators, we used whole genome array analysis to profile paired lesional and nonlesional psoriatic skin and skin from healthy donors.We observed robust overexpression of type I interferon (IFN)–inducible genes and genomic signatures that indicate T cell and dendritic cell infiltration in lesional skin. Up-regulation of mRNAs for IFN-α subtypes was observed in lesional skin compared with nonlesional skin. Enrichment of mature dendritic cells and 2 type I IFN–inducible proteins, STAT1 and ISG15, were observed in the...
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absenc...
Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility loci have...
Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences sug...
Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface...
BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiat...
Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal proliferation. ...
textabstractThe epidermal phenotype as observed in psoriatic skin results from inflammation and abno...
Psoriasis is a chronic autoimmune skin disease that can often be triggered upon skin injury, known a...
The epidermal phenotype as observed in psoriatic skin results from inflammation and abnormal prolife...
BACKGROUND:Evidence has shown that psoriasis is closely associated with infection; however, the mech...
Background: Type 1 T cells are hypothesized to be central in the immunopathogenesis of psoriasis. Th...
<div><p>Background</p><p>Evidence has shown that psoriasis is closely associated with infection; how...
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absenc...
<div><p>Background</p><p>Whole-genome expression profiling has been used to characterize molecular-l...
BACKGROUND: Whole-genome expression profiling has been used to characterize molecular-level differen...
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absenc...
Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility loci have...
Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences sug...
Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiation, surface...
BACKGROUND: Psoriasis is an immune-mediated disease characterized by aberrant epidermal differentiat...
Psoriasis is a chronic inflammatory skin disease characterized by abnormal epidermal proliferation. ...
textabstractThe epidermal phenotype as observed in psoriatic skin results from inflammation and abno...
Psoriasis is a chronic autoimmune skin disease that can often be triggered upon skin injury, known a...
The epidermal phenotype as observed in psoriatic skin results from inflammation and abnormal prolife...
BACKGROUND:Evidence has shown that psoriasis is closely associated with infection; however, the mech...
Background: Type 1 T cells are hypothesized to be central in the immunopathogenesis of psoriasis. Th...
<div><p>Background</p><p>Evidence has shown that psoriasis is closely associated with infection; how...
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absenc...
<div><p>Background</p><p>Whole-genome expression profiling has been used to characterize molecular-l...
BACKGROUND: Whole-genome expression profiling has been used to characterize molecular-level differen...
The inflammatory response is normally limited by mechanisms regulating its resolution. In the absenc...
Psoriasis is a common inflammatory skin disorder for which multiple genetic susceptibility loci have...
Psoriasis is the most common skin disease in adults. Current experimental and clinical evidences sug...