Expression Thereby Regulating PC1/3 Dependent Proinsulin Processing
- Liu Ting
- Zhao Yanxia
- Tang Na
- Feng Ruopeng
- Yang Xiaolong
- Lu Nicole
- Wen Jinhua
- Li Lingsong
DOIAbstract
mutation alters the activity of PC1/3, which affects proinsulin processing. knock-down inhibited proinsulin processing and that this effect could be rescued by proSAAS down-regulation. These findings confirm that Pax6 regulates proinsulin processing partially through proSAAS-mediated PC1/3 processing and activity. deficiency-caused diabetes
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