AbstractThe inner ear develops from an ectodermal placode that is specified by inductive signals from the adjacent neurectoderm and underlying mesoderm. In chick, fibroblast growth factor (Fgf)-19 is expressed in mesoderm underlying the presumptive otic placode, and human FGF19 induces expression of otic markers in a tissue explant containing neural plate and surface ectoderm. We show here that mouse Fgf15 is the sequence homolog of chick and human Fgf19/FGF19. In addition, we show that FGF15, like FGF19, is sufficient to induce expression of otic markers in a chick explant assay, suggesting that these FGFs are orthologs. Mouse embryos lacking Fgf15, however, do not have otic abnormalities at E9.5–E10.5, suggesting that Fgf15 is not uniquel...
Fgf3 has long been implicated in otic placode induction and early development of the otocyst; howeve...
on to the early requirement for Fgf signaling, the abnormal differentiation of inner ear structures ...
Fgf and Wnt signalling have been shown to be required for formation of the otic placode in vertebrat...
AbstractThe inner ear develops from an ectodermal placode that is specified by inductive signals fro...
AbstractThe inner ear epithelium, with its complex array of sensory, non-sensory, and neuronal cell ...
<div><p>The inner ear develops from a patch of thickened cranial ectoderm adjacent to the hindbrain ...
The inner ear develops from a patch of thickened cranial ectoderm adjacent to the hindbrain called t...
FGF signaling is required during multiple stages of inner ear development in many different vertebra...
AbstractFGF signaling is required during multiple stages of inner ear development in many different ...
Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and org...
Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and org...
Fibroblast growth factor (FGF) signaling is crucial for the induction and growth of the ear, a senso...
AbstractVertebrate cranial sensory organs are derived from region at the border of the anterior neur...
AbstractThe development of the otic placode is believed to depend on an inductive signal from the ad...
Four different fibroblast growth factor receptors (FGFR) are known, three of which have splice varia...
Fgf3 has long been implicated in otic placode induction and early development of the otocyst; howeve...
on to the early requirement for Fgf signaling, the abnormal differentiation of inner ear structures ...
Fgf and Wnt signalling have been shown to be required for formation of the otic placode in vertebrat...
AbstractThe inner ear develops from an ectodermal placode that is specified by inductive signals fro...
AbstractThe inner ear epithelium, with its complex array of sensory, non-sensory, and neuronal cell ...
<div><p>The inner ear develops from a patch of thickened cranial ectoderm adjacent to the hindbrain ...
The inner ear develops from a patch of thickened cranial ectoderm adjacent to the hindbrain called t...
FGF signaling is required during multiple stages of inner ear development in many different vertebra...
AbstractFGF signaling is required during multiple stages of inner ear development in many different ...
Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and org...
Members of the fibroblast growth factor (FGF) gene family control formation of the body plan and org...
Fibroblast growth factor (FGF) signaling is crucial for the induction and growth of the ear, a senso...
AbstractVertebrate cranial sensory organs are derived from region at the border of the anterior neur...
AbstractThe development of the otic placode is believed to depend on an inductive signal from the ad...
Four different fibroblast growth factor receptors (FGFR) are known, three of which have splice varia...
Fgf3 has long been implicated in otic placode induction and early development of the otocyst; howeve...
on to the early requirement for Fgf signaling, the abnormal differentiation of inner ear structures ...
Fgf and Wnt signalling have been shown to be required for formation of the otic placode in vertebrat...