Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmodulating the response are ill defined. In this issue of Immunity, Rajput et al. (2011) describe caspase-8-mediated RIP1 cleavage as a key step for restricting RIG-I signaling
Summary: Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including melanoma differenti...
Retinoic acid-inducible gene I (RIG-I) is a key sensor for viral RNA in the cytosol, and it initiate...
Summary: The innate immune sensor RIG-I must sensitively detect and respond to viral RNAs that enter...
Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmo...
SummaryExcessive responses to pattern-recognition receptors are prevented by regulatory mechanisms t...
Activation of antiviral responses by RNA sensors RIG-I and MDA5 must be stringently controlled. In t...
The innate immune system is essential for controlling viral infections, but several viruses have evo...
Caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory ...
Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory...
Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. ...
<p>(A) Caspase-1 deficient and BL/6 BMDM were infected as indicated and lysed at 8 h pi. DEVDase act...
International audienceBACKGROUND: RIG-I is a pivotal receptor that detects numerous RNA and DNA viru...
RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that triggers the alpha...
The innate immune system is our first line of defense against viral pathogens. Host cell pattern rec...
In vertebrates, the first line of defense against pathogen invasion involves the recognition of mole...
Summary: Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including melanoma differenti...
Retinoic acid-inducible gene I (RIG-I) is a key sensor for viral RNA in the cytosol, and it initiate...
Summary: The innate immune sensor RIG-I must sensitively detect and respond to viral RNAs that enter...
Activation of the RIG-I signaling molecule is essential for antiviral immunity but mechanisms downmo...
SummaryExcessive responses to pattern-recognition receptors are prevented by regulatory mechanisms t...
Activation of antiviral responses by RNA sensors RIG-I and MDA5 must be stringently controlled. In t...
The innate immune system is essential for controlling viral infections, but several viruses have evo...
Caspase-1 is an inflammatory caspase that controls the activation and secretion of the inflammatory ...
Caspase-8 is required for extrinsic apoptosis, but is also central for preventing a pro-inflammatory...
Viruses have evolved a remarkable array of strategies to escape the host's innate immune responses. ...
<p>(A) Caspase-1 deficient and BL/6 BMDM were infected as indicated and lysed at 8 h pi. DEVDase act...
International audienceBACKGROUND: RIG-I is a pivotal receptor that detects numerous RNA and DNA viru...
RIG-I is an intracellular RNA virus sensor that mediates a signaling pathway that triggers the alpha...
The innate immune system is our first line of defense against viral pathogens. Host cell pattern rec...
In vertebrates, the first line of defense against pathogen invasion involves the recognition of mole...
Summary: Retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs), including melanoma differenti...
Retinoic acid-inducible gene I (RIG-I) is a key sensor for viral RNA in the cytosol, and it initiate...
Summary: The innate immune sensor RIG-I must sensitively detect and respond to viral RNAs that enter...
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