Polymorphism rs401681 Contributes to Cancers Risk: Evidence from a Meta-Analysis Based on 29 Publications
- Yin Jieyun
- Li Yangkai
- Yin Ming
- Sun Jingwen
- Liu Li
- Qin Qin
- Li Xiaorong
- Long Lu
- Nie Shaofa
- Wei Sheng
DOIAbstract
polymorphism rs401681 was of special interest for cancers risk but with inconclusive results.<0.001) and an expected power of 1.000. Following further stratified analyses, the increased cancers risk were discovered in subgroups of lung, bladder, prostate, basal cell carcinomas and Asians, while a declined risk of pancreatic cancer and melanoma were detected.These findings suggested that rs401681 C allele was a low-penetrance risk allele for the development of cancers of lung, bladder, prostate and basal cell carcinoma, but a potential protective allele for melanoma and pancreatic cancer
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