LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

LPS involved in periodontal pathogenesis remains unclear, due to limited understanding of the specific receptors and signaling pathways involved in LPS-host cell interactions.-induced expression of IL-6 and IL-8 in HGFs. to evade innate host defense in gingival tissues, thereby contributing to periodontal pathogenesis