Increased CSF Levels of Phosphorylated Neurofilament Heavy Protein following Bout in Amateur Boxers

ε4 allele genotype which has been associated with poor outcome after TBI.Thirty amateur boxers with a minimum of 45 bouts and 25 non-boxing matched controls were included in a prospective cohort study. CSF and blood were collected at one occasion between 1 and 6 days after a bout, and after a rest period for at least 14 days (follow up). The controls were tested once. CSF levels of neurofilament heavy (pNFH), amyloid precursor proteins (sAPPα and sAPPβ), ApoE and ApoA1 were analyzed. In blood, plasma levels of Aβ42 and ApoE genotype were analyzed. ε4 allele had similar biomarker concentrations as non-carriers. ε4 allele was not found to influence biomarker levels after acute TBI