Cells Represent Highly Functional Endothelial Progenitor Cells in Murine Bone Marrow

Endothelial progenitor cells (EPCs) were shown to have angiogenic potential contributing to neovascularization. However, a clear definition of mouse EPCs by cell surface markers still remains elusive. We hypothesized that CD34 could be used for identification and isolation of functional EPCs from mouse bone marrow. cell-injected group, giving a possible explanation for significant reduction in fibrosis area, significant increase in neovascularization and the best cardiac functional recovery in this group in comparison with the others. cells may represent a functional EPC population in bone marrow, which could benefit the investigation of therapeutic EPC biology