Generated Conditioned Medium Can Replace Progenitor Cell Transplantation
- Di Santo Stefano
- Yang Zijiang
- Wyler von Ballmoos Moritz
- Voelzmann Jan
- Diehm Nicolas
- Baumgartner Iris
- Kalka Christoph
DOIAbstract
Current evidence suggests that endothelial progenitor cells (EPC) contribute to ischemic tissue repair by both secretion of paracrine factors and incorporation into developing vessels. We tested the hypothesis that cell-free administration of paracrine factors secreted by cultured EPC may achieve an angiogenic effect equivalent to cell therapy. cells/HPF, P<0.001) 3 days after the last injection.Intramuscular injection of EPC-CM is as effective as cell transplantation for promoting tissue revascularization and functional recovery. Owing to the technical and practical limitations of cell therapy, cell free conditioned media may represent a potent alternative for therapeutic angiogenesis in ischemic cardiovascular diseases
Add to ORKG