Molecular Evolution of Enterovirus 68 Detected in the Philippines
- Imamura Tadatsugu
- Suzuki Akira
- Lupisan Socorro
- Okamoto Michiko
- Aniceto Rapunzel
- Egos Rutchie J.
- Daya Edgardo E.
- Tamaki Raita
- Saito Mariko
- Fuji Naoko
- Roy Chandra Nath
- Opinion Jaime M.
- Santo Arlene V.
- Macalalad Noel G.
- Tandoc Amado
- Sombrero Lydia
- Olveda Remigio
- Oshitani Hitoshi
DOIAbstract
Detection of Enterovirus 68 (EV68) has recently been increased. However, underlying evolutionary mechanism of this increasing trend is not fully understood.Nasopharyngeal swabs were collected from 5,240 patients with acute respiratory infections in the Philippines from June 2009 to December 2011. EV68 was detected by polymerase chain reaction (PCR) targeting for 5′ untranslated region (5′UTR), viral protein 1 (VP1), and VP4/VP2. Phylogenetic trees were generated using the obtained sequences.<0.0001). Among VP1 sequences detected from 7 patients in 2011, 5 in lineage 2 were diverged from those detected in the Philippines in 2008, however, 2 in lineage 3 were not diverged from strains detected in the Philippines in 2008 but closely associated...
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