Polarizes a T-Cell Driven Arthritis Model towards Th17 Responses, Resulting in a More Destructive Arthritis
- Marijnissen Renoud J.
- Koenders Marije I.
- van de Veerdonk Frank L.
- Dulos John
- Netea Mihai G.
- Boots Annemieke M.H.
- Joosten Leo A.B.
- van den Berg Wim B.
DOIAbstract
in the arthritic joint altered the local cytokine environment, leading to enhanced Th17 expansion and resulting in a more destructive arthritis.s or Zymosan A. During the chronic phase of the arthritis, the cytokine levels, mRNA expression and histopathological analysis of the joints were performed. To investigate the phenotype of the IL-17 producing T-cells, synovial cells were isolated and analyzed by flowcytometry.-injected mice had significantly more Th17 cells in the synovium, of which a large population also produced IFN-γ., are very potent in interfering with the local cytokine environment in an arthritic joint, thereby polarizing arthritis towards a more destructive phenotype
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