Micronutrients in HIV: A Bayesian Meta-Analysis
- Carter George M.
- Indyk Debbie
- Johnson Matthew
- Andreae Michael
- Suslov Kathryn
- Busani Sudharani
- Esmaeili Aryan
- Sacks Henry S.
DOIAbstract
Approximately 28.5 million people living with HIV are eligible for treatment (CD4<500), but currently have no access to antiretroviral therapy. Reduced serum level of micronutrients is common in HIV disease. Micronutrient supplementation (MNS) may mitigate disease progression and mortality.We synthesized evidence on the effect of micronutrient supplementation on mortality and rate of disease progression in HIV disease.We searched MEDLINE, EMBASE, the Cochrane Central, AMED and CINAHL databases through December 2014, without language restriction, for studies of greater than 3 micronutrients versus any or no comparator. We built a hierarchical Bayesian random effects model to synthesize results. Inferences are based on the posterior distribut...
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