Endoplasmic Reticulum Stress, Unfolded Protein Response and Altered T Cell Differentiation in Necrotizing Enterocolitis
- Lu Peng
- Struijs Marie-Chantal
- Mei Jiaping
- Witte-Bouma Janneke
- Korteland-van Male Anita M.
- de Bruijn Adrianus C. J. M.
- van Goudoever Johannes B.
- Renes Ingrid B.
DOIAbstract
Endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) play important roles in chronic intestinal inflammation. Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency in preterm infants and is characterized by acute intestinal inflammation and necrosis. The objective of the study is to investigate the role of ER stress and the UPR in NEC patients. was detected using PCR, and gene expression was quantified using qPCR and Western blot. expression. expression levels, altered T cell differentiation and severe epithelial injury
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