AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen receptor repertoires. We review our current understanding of the V(D)J recombination reaction and how it is regulated during lymphocyte development. We also discuss how defects in the mechanism or regulation of V(D)J recombination can lead to human disease
A large number of lymphoid malignancies is characterized by specific chromosomal translocations, whi...
International audienceThe genes coding for the antigenic T cell receptor (TR) subunits are assembled...
Summary: The genes that encode immunoglobulins and T‐cell receptors must be assembled from the mult...
AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen recept...
AbstractV(D)J recombination assembles antigen receptor genes from component gene segments. We review...
International audienceThe V(D)J recombination machinery assembles antigen receptor genes from germli...
International audienceV(D)J recombination assembles antigen-specific immunoglobulin and T-cell recep...
International audienceChromosome breaks are dangerous business, carrying the risk of loss of genetic...
The diversity of antigen receptors expressed by the immune system is a function of developmentally r...
International audienceV(D)J recombination assembles antigen receptor genes from germline V, D and J ...
A diverse antibody repertoire is the backbone of a successful adaptive immune response. This diversi...
International audienceTo perform their specific functional role, B and T lymphocytes, cells of the a...
Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen rece...
In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H...
B-cells and T-cells are major components of immunity that detect a large variety of antigens that en...
A large number of lymphoid malignancies is characterized by specific chromosomal translocations, whi...
International audienceThe genes coding for the antigenic T cell receptor (TR) subunits are assembled...
Summary: The genes that encode immunoglobulins and T‐cell receptors must be assembled from the mult...
AbstractV(D)J recombination is of fundamental importance to the generation of diverse antigen recept...
AbstractV(D)J recombination assembles antigen receptor genes from component gene segments. We review...
International audienceThe V(D)J recombination machinery assembles antigen receptor genes from germli...
International audienceV(D)J recombination assembles antigen-specific immunoglobulin and T-cell recep...
International audienceChromosome breaks are dangerous business, carrying the risk of loss of genetic...
The diversity of antigen receptors expressed by the immune system is a function of developmentally r...
International audienceV(D)J recombination assembles antigen receptor genes from germline V, D and J ...
A diverse antibody repertoire is the backbone of a successful adaptive immune response. This diversi...
International audienceTo perform their specific functional role, B and T lymphocytes, cells of the a...
Lymphocytes recognize a vast variety of pathogens by expressing a diverse repertoire of antigen rece...
In this issue of Immunity, Liu et al. (2007) show that V(D)J recombinase binds chromatin marked by H...
B-cells and T-cells are major components of immunity that detect a large variety of antigens that en...
A large number of lymphoid malignancies is characterized by specific chromosomal translocations, whi...
International audienceThe genes coding for the antigenic T cell receptor (TR) subunits are assembled...
Summary: The genes that encode immunoglobulins and T‐cell receptors must be assembled from the mult...
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