Association between Gastroenterological Malignancy and Diabetes Mellitus and Anti-Diabetic Therapy: A Nationwide, Population-Based Cohort Study
- Lin Chien-Ming
- Huang Hui-Ling
- Chu Fang-Ying
- Fan Hueng-Chuen
- Chen Hung-An
- Chu Der-Ming
- Wu Li-Wei
- Wang Chung-Ching
- Chen Wei-Liang
- Lin Shih-Hua
- Ho Shinn-Ying
DOIAbstract
The relationship between diabetes mellitus (DM) and cancer incidence has been evaluated in limited kinds of cancer. The effect of anti-diabetic therapy (ADT) on carcinogenesis among diabetic patients is also unclear.Using population-based representative insurance claims data in Taiwan, 36,270 DM patients and 145,080 comparison subjects without DM were identified from claims from 2005 to 2010. The association between the top ten leading causes of cancer-related death in Taiwan and DM was evaluated. Whether ADT altered the risk of developing cancer was also investigated.<0.001). Among the oral types of ADT, metformin decreased the risk of lung and liver cancer, but had less effect on reducing the risk of colorectal cancer. α-glucosidase inhib...
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