A Novel Evolution-Based Method for Detecting Gene-Gene Interactions

for large-scale interactions analysis have been under development from several sources. Due to several difficult issues (e.g., sparseness of data in high dimensions and low replication or validation rate), development of fast, powerful and robust methods for detecting various forms of gene-gene interactions continues to be a challenging task. -based statistic is smaller than those obtained by the LD-based statistic or Poisson regression models.With rapidly growing large-scale genetic association studies, the proposed evolution-based method can be a promising tool in the identification of epistatic effects