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PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma

  • Karpel-Massler Georg
  • Pareja Fresia
  • Aimé Pascaline
  • Shu Chang
  • Chau Lily
  • Westhoff Mike-Andrew
  • Halatsch Marc-Eric
  • Crary John F.
  • Canoll Peter
  • Siegelin Markus D.
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Publication date
December 2014
Icon DOI
10.1371/journal.pone.0114583
Publisher
Public Library of Science

Abstract

., effects on tumor growth were examined in a murine subcutaneous xenograft model. when compared to treatment with each agent alone.PARP inhibition represents a promising avenue to overcome apoptotic resistance in GBM

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