Loss of Caveolin-1 Accelerates Neurodegeneration and Aging
- Head Brian P.
- Peart Jason N.
- Panneerselvam Mathivadhani
- Yokoyama Takaakira
- Pearn Matthew L.
- Niesman Ingrid R.
- Bonds Jacqueline A.
- Schilling Jan M.
- Miyanohara Atsushi
- Headrick John
- Ali Sameh S.
- Roth David M.
- Patel Piyush M.
- Patel Hemal H.
DOIAbstract
The aged brain exhibits a loss in gray matter and a decrease in spines and synaptic densities that may represent a sequela for neurodegenerative diseases such as Alzheimer's. Membrane/lipid rafts (MLR), discrete regions of the plasmalemma enriched in cholesterol, glycosphingolipids, and sphingomyelin, are essential for the development and stabilization of synapses. Caveolin-1 (Cav-1), a cholesterol binding protein organizes synaptic signaling components within MLR. It is unknown whether loss of synapses is dependent on an age-related loss of Cav-1 expression and whether this has implications for neurodegenerative diseases such as Alzheimer's disease. decreased Aβ expression.Therefore, Cav-1 represents a novel control point for healthy neuro...
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