Resveratrol Possesses Protective Effects in a Pristane-Induced Lupus Mouse Model

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has been found to satisfactorily treat SLE. SIRT1 deficiency results in the development of an autoimmune syndrome in mice, including a high titer of anti-nuclear antibody in serum, immunoglobulin deposition in the kidney, and immune complex glomerulonephritis. Resveratrol is an activator of SIRT1 and possesses anti-inflammation and immune-regulatory properties.To evaluate the preventative effects of resveratrol on a pristane-induced lupus animal model and assess its putative immune modulation effects. and assessed by flow cytometry. antibody production and proliferation of B cells were also inhibited.Resveratrol possesses protective effects in pristane-induced lupus mice and may represent a novel approach for the management of SLE