Neuropeptides are critical integrative elements within the central circadian clock in the suprachiasmatic nucleus (SCN), where they mediate both cell-to-cell synchronization and phase adjustments that cause light entrainment. Forward peptidomics identified little SAAS, derived from the proSAAS prohormone, among novel SCN peptides, but its role in the SCN is poorly understood.Little SAAS localization and co-expression with established SCN neuropeptides were evaluated by immunohistochemistry using highly specific antisera and stereological analysis. Functional context was assessed relative to c-FOS induction in light-stimulated animals and on neuronal circadian rhythms in glutamate-stimulated brain slices. We found that little SAAS-expressing...
Several distinct neuronal populations can be outlined in the suprachiasmatic nucleus (SCN) by employ...
The suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker in mammals and entrai...
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and ...
Neuropeptides are critical integrative elements within the central circadian clock in the suprachias...
Circadian rhythms affect human health and well-being by temporally organizing biological processes a...
International audienceRhythmic biological functions in mammals are orchestrated by a circadian timek...
International audienceThe daily temporal organization of rhythmic functions in mammals, which requir...
Abstract Background In mammals, the brain clock responsible for generating circadian rhythms is loca...
The body’s master clock lies at the base of the hypothalamus immediately above the optic chiasm. Bec...
In mammals the suprachiasmatic nucleus (SCN), the master circadian clock, is sensitive to light inpu...
mammals, the circadian oscillators that drive daily behavioral and endocrine rhythms are located in ...
The neuropeptide vasoactive intestinal peptide (VIP) is expressed at high levels in a subset of neur...
Biological oscillations with an endogenous period of near 24 h (circadian rhythms) are generated by ...
The circadian clock in the suprachiasmatic nuclei (SCN) is composed of thousands of oscillator neuro...
The suprachiasmatic nucleus (SCN) of the hypothalamus is the neural locus of the circadian clock. To...
Several distinct neuronal populations can be outlined in the suprachiasmatic nucleus (SCN) by employ...
The suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker in mammals and entrai...
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and ...
Neuropeptides are critical integrative elements within the central circadian clock in the suprachias...
Circadian rhythms affect human health and well-being by temporally organizing biological processes a...
International audienceRhythmic biological functions in mammals are orchestrated by a circadian timek...
International audienceThe daily temporal organization of rhythmic functions in mammals, which requir...
Abstract Background In mammals, the brain clock responsible for generating circadian rhythms is loca...
The body’s master clock lies at the base of the hypothalamus immediately above the optic chiasm. Bec...
In mammals the suprachiasmatic nucleus (SCN), the master circadian clock, is sensitive to light inpu...
mammals, the circadian oscillators that drive daily behavioral and endocrine rhythms are located in ...
The neuropeptide vasoactive intestinal peptide (VIP) is expressed at high levels in a subset of neur...
Biological oscillations with an endogenous period of near 24 h (circadian rhythms) are generated by ...
The circadian clock in the suprachiasmatic nuclei (SCN) is composed of thousands of oscillator neuro...
The suprachiasmatic nucleus (SCN) of the hypothalamus is the neural locus of the circadian clock. To...
Several distinct neuronal populations can be outlined in the suprachiasmatic nucleus (SCN) by employ...
The suprachiasmatic nucleus (SCN) functions as the central circadian pacemaker in mammals and entrai...
Individual neurons in the suprachiasmatic nuclei (SCN) contain an intracellular molecular clock and ...