Graft-Versus-Host Disease Prophylaxis after Transplantation: A Network Meta-Analysis

Ziakas Panayiotis D.
Zervou Fainareti N.
Zacharioudakis Ioannis M.
Mylonakis Eleftherios

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Publication date

December 2014

DOI

10.1371/journal.pone.0114735

Publisher

Public Library of Science

Abstract

Graft-versus-host Disease (GvHD) prophylaxis after allogeneic hematopoietic stem-cell transplantation (HSCT) is an ongoing effort but relative effects of different policies are not systematically explored.We systematically reviewed 30-year evidence on GvHD prophylaxis and quantified the relative effect of different policies using a network meta-analysis. We searched PubMed and the Cochrane Library for randomized studies on the topic. The primary outcome of interest was grade II-IV acute GvHD over 0 or I (with odds ratio OR <1 denoting benefit).Thirty-three eligible studies that enrolled 3,440 patients (published up to June 2014), provided data on seven immunosuppressive drugs namely cyclosporin A (CsA), methotrexate (MTX), anti-thymocyte gl...