Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study
- Lingappa Jairam R.
- Kahle Erin
- Mugo Nelly
- Mujugira Andrew
- Magaret Amalia
- Baeten Jared
- Bukusi Elizabeth A.
- Cohen Craig R.
- Katabira Elly
- Ronald Allan
- Kiarie James
- Farquhar Carey
- Stewart Grace John
- Makhema Joseph
- Essex M.
- Were Edwin
- Fife Kenneth
- deBruyn Guy
- Gray Glenda
- McIntyre James
- Manongi Rachel
- Kapiga Saidi
- Coetzee David
- Allen Susan
- Inambao Mubiana
- Kayitenkore Kayitesi
- Karita Etienne
- Kanweka William
- Delany Sinead
- Rees Helen
- Vwalika Bellington
- Coombs Robert W.
- Morrow Rhoda
- Whittington William
- Corey Lawrence
- Wald Anna
- Celum Connie
DOIAbstract
The Partners HSV-2/HIV-1 Transmission Study (Partners Study) is a phase III, placebo-controlled trial of daily acyclovir for genital herpes (HSV-2) suppression among HIV-1/HSV-2 co-infected persons to reduce HIV-1 transmission to their HIV-1 susceptible partners, which requires recruitment of HIV-1 serodiscordant heterosexual couples. We describe the baseline characteristics of this cohort.HIV-1 serodiscordant heterosexual couples, in which the HIV-1 infected partner was HSV-2 seropositive, had a CD4 count ≥250 cells/mcL and was not on antiretroviral therapy, were enrolled at 14 sites in East and Southern Africa. Demographic, behavioral, clinical and laboratory characteristics were assessed. copies/mL for CD4 350–499 and >500 relative to <3...
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