Genetic Variants and Insulin Resistance

are both important for insulin signaling and β-cell function, but their associations with glucose-related traits are unclear. variants with glucose-related traits and potential interaction with dietary fat.We first investigated genetic associations and their modulation by dietary fat in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 820). Nine single-nucleotide polymorphisms (SNPs) were selected for analysis, covering more than 80% of the SNPs in the region. We then sought to replicate the findings in the Boston Puerto Rican Health Study (BPRHS) (n = 844).-interaction = 0.034). variants are associated with insulin resistance in populations of different ancestries, and are modified by dietary PUFA