Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced the cleavage-secretion process. Recently, we found a family whose affected members had a 6-fold increase in blood ACE and a Tyr465Asp (Y465D) substitution, distal to the stalk region, in the N domain of ACE.HEK and CHO cells expressing mutant (Tyr465Asp) ACE demonstrate a 3- and 8-fold increase, respectively, in the rate of ACE shedding compar...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
We describe a novel mutation of the ACE gene associated with a major familial elevation of circulati...
Background: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and pla...
BACKGROUND: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and pla...
Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key rol...
Angiotensin-converting enzyme (ACE), an enzyme that plays a major role in vasoactive peptide metabol...
BACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small peptides and plays a key role...
Contains fulltext : 178497.pdf (Publisher’s version ) (Open Access)Angiotensin-con...
BACKGROUND: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active pep...
textabstractBackground: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologicall...
BACKGROUND: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active pep...
Item does not contain fulltextBACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small...
Background: Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in bl...
BACKGROUND:Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blo...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
We describe a novel mutation of the ACE gene associated with a major familial elevation of circulati...
Background: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and pla...
BACKGROUND: Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and pla...
Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key rol...
Angiotensin-converting enzyme (ACE), an enzyme that plays a major role in vasoactive peptide metabol...
BACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small peptides and plays a key role...
Contains fulltext : 178497.pdf (Publisher’s version ) (Open Access)Angiotensin-con...
BACKGROUND: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active pep...
textabstractBackground: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologicall...
BACKGROUND: Angiotensin-converting enzyme (ACE) (EC 4.15.1) metabolizes many biologically active pep...
Item does not contain fulltextBACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small...
Background: Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in bl...
BACKGROUND:Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blo...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
Angiotensin-converting enzyme (ACE) metabolizes many peptides and plays a key role in blood pressure...
We describe a novel mutation of the ACE gene associated with a major familial elevation of circulati...