A Genome-Wide Investigation of MicroRNA Expression Identifies Biologically-Meaningful MicroRNAs That Distinguish between High-Risk and Low-Risk Intraductal Papillary Mucinous Neoplasms of the Pancreas
- Permuth-Wey Jennifer
- Chen Y. Ann
- Fisher Kate
- McCarthy Susan
- Qu Xiaotao
- Lloyd Mark C.
- Kasprzak Agnieszka
- Fournier Michelle
- Williams Vonetta L.
- Ghia Kavita M.
- Yoder Sean J.
- Hall Laura
- Georgeades Christina
- Olaoye Funmilayo
- Husain Kazim
- Springett Gregory M.
- Chen Dung-Tsa
- Yeatman Timothy
- Centeno Barbara Ann
- Klapman Jason
- Coppola Domenico
- Malafa Mokenge
DOIAbstract
Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic ductal adenocarcinoma (PDAC) precursors. Differentiating between high-risk IPMNs that warrant surgical resection and low-risk IPMNs that can be monitored is a significant clinical problem, and we sought to discover a panel of mi(cro)RNAs that accurately classify IPMN risk status.<0.10).This pilot study highlights miRNAs that may aid in preoperative risk stratification of IPMNs and provides novel insights into miRNA-mediated progression to pancreatic malignancy. The miRNAs identified here and in other recent investigations warrant evaluation in biofluids in a well-powered prospective cohort of individuals newly-diagnosed with IPMNs and other pancreatic cysts and those at increas...
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