Gene Rearrangement in Lung Adenocarcinoma: Comparison of IHC, FISH and Real-Time RT-PCR

-positive lung adenocatcinoma (ADC) patients. fusion status was examined by FISH and qRT-PCR assay. fusion were 100% and 85.1%, respectively. The total concordance rate between IHC and qRT-PCR were 93.3%.IHC is a reliable and rapid screening tool in routine pathologic laboratories for the identification of suitable candidates for ROS1-targeted therapy. Some ROS1 IHC-positive but FISH-negative cases did harbor the translocation events and may benefit from crizotinib