Influences Brain Atrophy in Multiple Sclerosis

Brain atrophy and cognitive dysfunction are neurodegenerative features of Multiple Sclerosis (MS). We used a candidate gene approach to address whether genetic variants implicated in susceptibility to late onset Alzheimer's Disease (AD) influence brain volume and cognition in MS patients. = 0.0089) at the last MRI visit. allele associated with AD-susceptibility, yielding new insights into potentially shared neurodegenerative process between MS and late onset AD