Replication Inhibition of Hepatitis B Virus and Hepatitis C Virus in Co-Infected Patients in Chinese Population
- Yu Ge
- Chi Xiumei
- Wu Ruihong
- Wang Xiaomei
- Gao Xiuzhu
- Kong Fei
- Feng Xiangwei
- Gao Yuanda
- Huang Xinxing
- Jin Jinglan
- Qi Yue
- Tu Zhengkun
- Sun Bing
- Zhong Jin
- Pan Yu
- Niu Junqi
DOIAbstract
Hepatitis B virus (HBV) and hepatitis C virus (HCV) co-infections contributes to a substantial proportion of liver disease worldwide. The aim of this study was to assess the clinical and virological features of HBV-HCV co-infection.Demographic data were collected for 3238 high-risk people from an HCV-endemic region in China. Laboratory tests included HCV antibody and HBV serological markers, liver function tests, and routine blood analysis. Anti-HCV positive samples were analyzed for HCV RNA levels and subgenotypes. HBsAg-positive samples were tested for HBV DNA. IU/mL, respectively; P<0.001). The HBV-HCV co-infection group had higher ALT, AST, ALP, GGT, APRI and FIB-4 levels, but lower ALB and total platelet compared to the HBV mono-infect...
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