F]-FMISO Tumor Hypoxia Accumulation

F]-FMISO in a preclinical model of tumor hypoxia.F]-FMISO (40–60% versus 70% reduction as compared to awake animals breathing air).The use of anaesthesia can have profound effects on the experimental outcome. More importantly, all tested anaesthetics reduced tumor-hypoxia uptake. Anaesthesia cannot be avoided in preclinical studies but great care has to be taken in preclinical models of hypoxia as anaesthesia effects cannot be generalised across applications, nor disease states