Adenosine Kinase Complexed with Inhibitor and Activator: Implications for Catalysis and Hyperactivation

bears interesting catalytic enzymes for chemotherapeutic intervention of Human African Trypanosomiasis. Unlike mammalian cells, trypanosomes lack de novo purine synthesis and completely rely on salvage from their hosts. One of the key enzymes is adenosine kinase which catalyzes the phosphorylation of ingested adenosine to form adenosine monophosphate (AMP) utilizing adenosine triphosphate (ATP) as the preferred phosphoryl donor.) at 2.8 Å resolution. support the observed binding mode of the activator and provide a possible mechanism of action with respect to their activating effect towards TbrAK