AbstractLet Cay(S:H) be the Cayley digraph of the generators S in the group H. A one-way infinite Hamiltonian path in the digraph G is a listing of all the vertices [νi:1⩽i<∞], such that there is an arc from νi to ν1+1. A two-way infinite Hamiltonian path is similarly defined, with i ranging from −∞ to ∞. In this paper, we give conditions on S and H for the existence of one- and two-way infinite Hamiltonian paths in Cay(X:H). Two of our results can be summarized as follows. First, if S is countably infinite and H is abelian, then Cay(S:H) has one- and two-way Hamiltonian paths if and only if it is strongly connected (except for one infinite family). We also give necessary and sufficient conditions on S for Cay(S:H) to be strongly connected ...