Meta-Analysis of the rs4779584 Polymorphism and Colorectal Cancer Risk

and colorectal cancer.We selected 12 case-control studies involving 11,769 cases of CRC and 14,328 healthy controls. The association between the rs4779584 polymorphism and CRC was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used different genetic model analyses, sensitivity analyses, and assessments of bias in our meta-analysis. rs4779584 polymorphisms were associated with CRC in all of the genetic models that were examined in this meta-analysis of 12 case-control studies. rs4779584 polymorphisms may increase the risk of developing colorectal cancer