Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much greater risk for developing pulmonary arterial hypertension (PAH). However, not all carriers of a mutation in the BMPR2 gene suffer from PAH. We have previously shown that prolonged T helper 2 (Th2) responses in the lungs to a mild antigen delivered via the airways induce severe pulmonary arterial remodeling, but no pulmonary hypertension. The current studies were designed to test the idea that Th2 responses to a mild antigen together with the expression of a hypomorphic BMPR2 gene would trigger pulmonary hypertension.Mice that expressed a hypomorphic BMPR2 transgene (transgene-positive) and transgene-negative mice were either exposed to saline, or primed a...
Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed in 70 % of pati...
Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the deve...
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but e...
Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much greater risk fo...
Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much greater risk fo...
Background: Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much gre...
Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been ...
Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable ...
Background - Pulmonary arterial hypertension (PAH) is a rare but fatal lung disease of diverse origi...
Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 ...
Pulmonary arterial hypertension (PAH) is a rare and fatal disease caused by excessive remodelling of...
Background: Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients wi...
Rationale: Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in up to 70% of ...
International audienceBACKGROUND: Monoallelic mutations in the gene encoding bone morphogenetic prot...
Abstract As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common geneti...
Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed in 70 % of pati...
Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the deve...
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but e...
Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much greater risk fo...
Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much greater risk fo...
Background: Hypomorphic mutations in the bone morphogenic protein receptor (BMPR2) confer a much gre...
Loss-of-function mutations in the bone morphogenetic protein receptor type 2 (BMPR2) gene have been ...
Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients with heritable ...
Background - Pulmonary arterial hypertension (PAH) is a rare but fatal lung disease of diverse origi...
Patients with familial pulmonary arterial hypertension inherit heterozygous mutations of the type 2 ...
Pulmonary arterial hypertension (PAH) is a rare and fatal disease caused by excessive remodelling of...
Background: Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in patients wi...
Rationale: Bone morphogenetic protein receptor type 2 (BMPR2) mutations are present in up to 70% of ...
International audienceBACKGROUND: Monoallelic mutations in the gene encoding bone morphogenetic prot...
Abstract As bone morphogenetic protein receptor type II (Bmpr2) mutations are the most common geneti...
Mutations in the bone morphogenetic protein receptor (BMPR2) gene have been observed in 70 % of pati...
Background: Mutations in bone morphogenetic protein receptor type II (BMPR2) are leading to the deve...
The pathogenesis of idiopathic pulmonary arterial hypertension (IPAH) is not fully understood, but e...