N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryonic lethal. During the secretory stage of enamel development, E-cadherin is down-regulated and N-cadherin is specifically up-regulated in ameloblasts when groups of ameloblasts slide by one another to form the rodent decussating enamel rod pattern. Since N-cadherin promotes cell migration, we asked if N-cadherin is essential for ameloblast cell movement during enamel development.The enamel organ, including its ameloblasts, is an epithelial tissue and for this study a mouse strain with N-cadherin ablated from epithelium was generated. Enamel from wild-type (WT) and N-cadherin conditional knockout (cKO) mice was analyzed. μCT and scanning electron microsco...
AbstractStem cells are essential for the regeneration and homeostasis of many organs, such as tooth,...
<p>qPCR was performed on WT and N-cadherin cKO postnatal day-5 enamel organs with 7 mice assessed pe...
Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, s...
N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryonic lethal. ...
Background: N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryo...
<p>(<b>a</b>) qPCR analysis of N-cadherin gene expression in wild-type (WT) and N-cadherin condition...
<p>In the less mature second molar (M2), N-cadherin was not expressed (A) in the enamel organ (EO) o...
<p>(<b>a</b>) N-cadherin cKO mice have normal enamel mineral levels. WT and N-cadherin cKO hemi-mand...
Dental enamel development occurs in stages. The ameloblast cell layer is adjacent to, and is respons...
N-cadherin is a well-studied classic cadherin involved in multiple developmental processes and is al...
<p>qPCR was performed on WT and N-cadherin cKO postnatal day-5 enamel organs. <i>Bmp2</i> expression...
To investigate the expression patterns of E-cadherin and P-cadherin in murinetooth germs at early de...
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in...
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in...
Cell adhesion molecules play essential roles in the development and disease of tooth and oral struct...
AbstractStem cells are essential for the regeneration and homeostasis of many organs, such as tooth,...
<p>qPCR was performed on WT and N-cadherin cKO postnatal day-5 enamel organs with 7 mice assessed pe...
Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, s...
N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryonic lethal. ...
Background: N-cadherin is a cell-cell adhesion molecule and deletion of N-cadherin in mice is embryo...
<p>(<b>a</b>) qPCR analysis of N-cadherin gene expression in wild-type (WT) and N-cadherin condition...
<p>In the less mature second molar (M2), N-cadherin was not expressed (A) in the enamel organ (EO) o...
<p>(<b>a</b>) N-cadherin cKO mice have normal enamel mineral levels. WT and N-cadherin cKO hemi-mand...
Dental enamel development occurs in stages. The ameloblast cell layer is adjacent to, and is respons...
N-cadherin is a well-studied classic cadherin involved in multiple developmental processes and is al...
<p>qPCR was performed on WT and N-cadherin cKO postnatal day-5 enamel organs. <i>Bmp2</i> expression...
To investigate the expression patterns of E-cadherin and P-cadherin in murinetooth germs at early de...
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in...
Mutations in the human enamelin gene cause autosomal dominant hypoplastic amelogenesis imperfecta in...
Cell adhesion molecules play essential roles in the development and disease of tooth and oral struct...
AbstractStem cells are essential for the regeneration and homeostasis of many organs, such as tooth,...
<p>qPCR was performed on WT and N-cadherin cKO postnatal day-5 enamel organs with 7 mice assessed pe...
Stem cells are essential for the regeneration and homeostasis of many organs, such as tooth, hair, s...