LED Fluorescence Microscopy for the Diagnosis of Pulmonary Tuberculosis: A Multi-Country Cross-Sectional Evaluation
- Cuevas Luis Eduardo
- Al-Sonboli Najla
- Lawson Lovett
- Yassin Mohammed Ahmed
- Arbide Isabel
- Al-Aghbari Nasher
- Bahadur Sherchand Jeevan
- Al-Absi Amin
- Emenyonu Emmanuel Nnamdi
- Merid Yared
- Okobi Mosis Ifenyi
- Onuoha Juliana Olubunmi
- Aschalew Melkamsew
- Aseffa Abraham
- Harper Greg
- Anderson de Cuevas Rachel Mary
- Theobald Sally Jane
- Nathanson Carl-Michael
- Joly Jean
- Faragher Brian
- Squire Stephen Bertel
- Ramsay Andrew
DOIAbstract
The diagnosis of tuberculosis (TB) in resource-limited settings relies on Ziehl-Neelsen (ZN) smear microscopy. LED fluorescence microscopy (LED-FM) has many potential advantages over ZN smear microscopy, but requires evaluation in the field. The aim of this study was to assess the sensitivity/specificity of LED-FM for the diagnosis of pulmonary TB and whether its performance varies with the timing of specimen collection.<0.001) specific. The sensitivity/specificity of ZN smear microscopy and LED-FM did not vary between SMS and SSM.LED-FM had higher sensitivity but, in this study, lower specificity than ZN smear microscopy for diagnosis of pulmonary TB. Performance was independent of the scheme used for collecting specimens. The introduction...
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