-3′UTR Is Required for Germ Cell Specific NANOS3 Expression in Mouse Embryos

The regulation of gene expression via a 3′ untranslated region (UTR) plays essential roles in the discrimination of the germ cell lineage from somatic cells during embryogenesis. This is fundamental to the continuation of a species. Mouse NANOS3 is an essential protein required for the germ cell maintenance and is specifically expressed in these cells. However, the regulatory mechanisms that restrict the expression of this gene in the germ cells is largely unknown at present.-3′UTR sequence to the coding region of exogenous gene was effective in restricting protein expression in germ cells.-3′UTR has an essential role in translational control in the mouse embryo