Men with Sickle Cell Anemia and Priapism Exhibit Increased Hemolytic Rate, Decreased Red Blood Cell Deformability and Increased Red Blood Cell Aggregate Strength
- Cita Kizzy-Clara
- Brureau Laurent
- Lemonne Nathalie
- Billaud Marie
- Connes Philippe
- Ferdinand Séverine
- Tressières Benoit
- Tarer Vanessa
- Etienne-Julan Maryse
- Blanchet Pascal
- Elion Jacques
- Romana Marc
DOIAbstract
To investigate the association between priapism in men with sickle cell anemia (SCA) and hemorheological and hemolytical parameters. using a cone/plate viscometer. A principal component analysis was performed on 4 hemolytic markers (i.e., lactate dehydrogenase (LDH), aspartate aminotransferase (ASAT), total bilirubin (BIL) levels and reticulocyte (RET) percentage) to calculate a hemolytic index. = 0.01) than controls.Our results confirm that priapism in SCA is associated with higher hemolytic rates and show for the first time that this complication is also associated with higher RBC aggregate strength and lower RBC deformability
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