Inoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a direct effect inhibiting mineralization of osteoblasts in vitro without impairing extracellular matrix production and expression of alkaline phosphatase. IP6 has been proposed to exhibit similar effects to those of bisphosphonates on bone resorption, however, its direct effect on osteoclasts (OCL) is presently unknown.The aim of the present study was to investigate the effect of IP6 on the RAW 264.7 monocyte/macrophage mouse cell line and on human primary osteoclasts. On one hand, we show that IP6 decreases the osteoclastogenesis in RAW 264.7 cells induced by RANKL, without affecting cell proliferation or cell viability. The number of TRAP po...
【Abstract】Objective: To observe the effect of recombinant interleukin-6 (IL-6) and osteoprotegerin (...
Osteoclasts are bone-resorptive cells that differentiate from hematopoietic precursors upon receptor...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...
Inoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a ...
<p>(A) Effect of IP6 treatment on the generation of multinucleated TRAP-positive cells (OCL). RAW 26...
<p>(A) Effect of IP6 treatment on the generation of multinucleated TRAP-positive cells (OCL). Human ...
<p>Mature osteoclasts were treated with 1 µM of IP6 for 24 hours and gene expression of osteoclast f...
The receptor activator of NF-κB ligand (RANKL) signal is an activator of tumor necrosis factor recep...
<p>(A) LDH activity measured from culture media collected after treatment of cells with different do...
Myo-inositol phosphates (IPs) are a large family of compounds that are ubiquitous in eukaryotes. The...
<p>Mature osteoclasts were treated with 1 µM of IP6 for 24 hours and gene expression of osteoclast p...
International audienceOsteoclasts are bone-resorptive cells that differentiate from hematopoietic pr...
SummaryOsteoporosis is a multifactorial genetic disease characterized by reduction of bone mass due ...
Prostate cancer (PCA) is the most common invasive malignancy and the second leading cause of cancerr...
ABBREVIATIONS: RANKL, receptor activator of NF-κB ligand; TRAF6, tumor necrosis factor receptor-asso...
【Abstract】Objective: To observe the effect of recombinant interleukin-6 (IL-6) and osteoprotegerin (...
Osteoclasts are bone-resorptive cells that differentiate from hematopoietic precursors upon receptor...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...
Inoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a ...
<p>(A) Effect of IP6 treatment on the generation of multinucleated TRAP-positive cells (OCL). RAW 26...
<p>(A) Effect of IP6 treatment on the generation of multinucleated TRAP-positive cells (OCL). Human ...
<p>Mature osteoclasts were treated with 1 µM of IP6 for 24 hours and gene expression of osteoclast f...
The receptor activator of NF-κB ligand (RANKL) signal is an activator of tumor necrosis factor recep...
<p>(A) LDH activity measured from culture media collected after treatment of cells with different do...
Myo-inositol phosphates (IPs) are a large family of compounds that are ubiquitous in eukaryotes. The...
<p>Mature osteoclasts were treated with 1 µM of IP6 for 24 hours and gene expression of osteoclast p...
International audienceOsteoclasts are bone-resorptive cells that differentiate from hematopoietic pr...
SummaryOsteoporosis is a multifactorial genetic disease characterized by reduction of bone mass due ...
Prostate cancer (PCA) is the most common invasive malignancy and the second leading cause of cancerr...
ABBREVIATIONS: RANKL, receptor activator of NF-κB ligand; TRAF6, tumor necrosis factor receptor-asso...
【Abstract】Objective: To observe the effect of recombinant interleukin-6 (IL-6) and osteoprotegerin (...
Osteoclasts are bone-resorptive cells that differentiate from hematopoietic precursors upon receptor...
Bisphosphonates inhibit bone resorption in vivo and in vitro by unknown mechanisms. The effect of bi...