and Infected Human Dendritic Cells and Macrophages

, a major human pathogen, and its human host cells, macrophages and dendritic cells. shows a marked stress response when inside dendritic cells, which is in accordance with the low permissivity of these specialized phagocytes to the tubercle bacillus and to other pathogens. In contrast, the mycobacterial transcriptome inside macrophages reflects that of replicating bacteria. On the host cell side, differential responses to infection in macrophages and dendritic cells were identified in genes involved in oxidative stress, intracellular vesicle trafficking and phagosome acidification. and in mycobacterial adaptation to different intracellular environments