Genetic Determinants for Body Iron Store and Type 2 Diabetes Risk in US Men and Women

High body iron store has been associated with an increased risk of type 2 diabetes (T2D); it remains unknown whether the genetic variants related to body iron status affect T2D risk. We aimed at comprehensively investigating the associations between the genetic variants related to body iron status and the T2D risk. were not associated with diabetes risk in either sex. Dietary iron intake did not modify the associations of the newly identified loci with diabetes risk. was nominally associated with a decreased risk of T2D in men but not in women. The apparent differences by gender warrant further study