Length Variations amongst Protein Domain Superfamilies and Consequences on Structure and Function
- Sandhya Sankaran
- Rani Saane Sudha
- Pankaj Barah
- Govind Madabosse Kande
- Offmann Bernard
- Srinivasan Narayanaswamy
- Sowdhamini Ramanathan
DOIAbstract
Related protein domains of a superfamily can be specified by proteins of diverse lengths. The structural and functional implications of indels in a domain scaffold have been examined.In this study, domain superfamilies with large length variations (more than 30% difference from average domain size, referred as ‘length-deviant’ superfamilies and ‘length-rigid’ domain superfamilies (<10% length difference from average domain size) were analyzed for the functional impact of such structural differences. Our delineated dataset, derived from an objective algorithm, enables us to address indel roles in the presence of peculiar structural repeats, functional variation, protein-protein interactions and to examine ‘domain contexts’ of proteins tolera...
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